In vivo PQQ supplementation elevated fecundity in reproductively aged mice by balancing hormones, harmonizing estrus cycles, and reducing ovarian fibrosis. It improved oocyte quality, including maturation, fertilization, and embryonic development, via restored mitochondrial dynamics and lysosomal function to reduce ROS and apoptosis. This suggests potential therapy for infertility in women of advanced maternal age.

A Mitsubishi Gas Chemical study in Frontiers in Aging showed PQQ supplementation in aging mice suppressed muscle atrophy and weakness by improving mitochondrial function and reducing oxidative stress and inflammation. It also mitigated malnutrition by enhancing metabolic function and intestinal performance. The findings highlight PQQ's anti-aging potential, building on prior evidence for mitochondrial biogenesis and nerve growth factor.

Pre-conditioning with PQQ during pregnancy protected against LPS-induced inflammation, reducing fetal demise, improving placental morphology, vascular integrity, and fetal growth in mice. It suppressed inflammation, oxidative stress, and aberrant gene expression under moderate LPS doses via antioxidant and mitochondrial-supporting properties. High-dose LPS limited protective effects.