A Toho University study published in the Journal of Pharmacological Sciences found that gamma-linolenic acid (GLA) relaxes constricted coronary arteries by acting as a competitive antagonist of TP receptors, similar to omega-3 fatty acids. This suggests dietary GLA supplementation could help prevent coronary spasms and angina, with concentrations achievable through diet. Further human studies are needed to confirm effects and safety.

This review in Medical Science Monitor details GLA's selective tumoricidal effects on glioma cells via apoptosis induction, free radical increase, and oncogene suppression, sparing normal cells. In three open-label clinical studies, intra-tumoral GLA injections significantly reduced gliomas with minimal side effects and low neurotoxicity. GLA also enhances anti-cancer drug efficacy and reverses resistance.

This peer-reviewed article in Frontiers in Bioengineering and Biotechnology reviews metabolic engineering and genetic optimization of organisms like Yarrowia lipolytica for enhanced GLA production, targeting health supplements and pharmaceuticals. It discusses biotechnological trends for commercial exploitation and GLA's potential in cancer treatment, though mostly in vitro. The paper follows PRISMA standards for rigorous analysis.