This peer-reviewed study in Nutrients (2026) assessed black pepper (piperine) as a bioenhancer for turmeric in reducing self-reported pain via ecological momentary assessment. Participants receiving turmeric with black pepper showed pain reductions, though similar to turmeric alone, with potential sustained benefits post-exposure. The trial highlights black pepper's role in enhancing curcumin absorption for pain management.

This randomized, double-blind, placebo-controlled trial published in Tropical Journal of Natural Product Research evaluated 500 mg/day black pepper capsules (7.16 mg piperine) over 12 weeks for lipid profile improvements. No significant changes in cholesterol levels were observed compared to placebo, though the supplement was safe with minor GI side effects. It provides clinical evidence on piperine's limited efficacy for hypercholesterolemia.

A University of Georgia clinical study found resveratrol (500 mg) combined with BioPerine black pepper extract (10 mg) increased skeletal muscle mitochondrial function after 4 weeks with exercise, measured via near-infrared spectroscopy. Published in Applied Physiology, Nutrition and Metabolism, it supports black pepper's role in enhancing bioavailability for heart health. Related ongoing Phase II B trial at Ohio State examines tocotrienols for stroke prevention.